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NMNH, akwụkwọ akụkọ na ike NAD precursor
2024-08-27 10:00:38
Nicotinamide adenine dinucleotide (NAD) homeostasis na-aga n'ihu n'ihi mmebi nke enzymes dabere na NAD. Ịgbakwunye NAD na NAD precursors nicotinamide mononucleotide (NMN) na nicotinamide riboside (NR) nwere ike ibelata ahaghị nhata a. Ụfọdụ ndị nchọpụta kọrọ usoro njikọ nke ụdị NMN belatara,NMNH, ma chọpụta molecule a dị ka ihe mmalite NAD ọhụrụ maka oge mbụ, ma kwenye na NMNH na-arụ ọrụ nke ọma karịa NMN na NR na-abawanye ọkwa NAD ma nwee ike ibelata nha tubule renal. Ebibiri mkpụrụ ndụ epithelial ma na-emeziwanye nrụzi ha. E bipụtara nsonaazụ ya na "FASEB Journal".
Njikọ Enzymatic nke NMNH: A na-eji ọrụ dị elu nke NAD pyrophosphatase sitere na Escherichia coli (EcNADD) kewaa NADH n'ime NMNH na AMP.
NMNHna-abawanye ọdịnaya NAD nke ọma:
Iji chọpụta ma NMNH nwere ike ịbawanye ọdịnaya NAD nke ọma, a na-etinye ntinye uche dị iche iche nke NMN na NMNH n'ime sel imeju nke ụmụ oke AML12. Nsonaazụ gosiri na na ntinye uche ọ bụla, NMNH mụbara ọkwa NAD dị elu karịa NMN. N'otu oge ahụ, ọkwa NAD mụbara nke ukwuu n'ime nkeji 15 site na iji NMNH dị ka ihe mbụ, na-egosi na NMNH bụ ngwa ngwa ngwa ngwa karịa NMN; ma tụnyere NMN, NMNH mụbara ọkwa NAD site na 1.3-2.4 ugboro. Inwe ike ịbawanye ọkwa NAD site na oge 5.2 ruo ugboro 37 na-egosi na NMNH bụ ihe mmalite dị irè maka njikọ NAD.
Iji tụnyere mmetụta nke NMNH na NMN, ndị nchọpụta na-agbanye PBS na 250 mg / kg nke NMN naNMNHn'ime ụmụ oke C57BL/6N, n'otu n'otu, wee duzie nlele ọbara n'usoro. Nsonaazụ gosiri na NMNH mụbara ọkwa NAD n'ọbara nke ukwuu, ruo n'ókè dị ukwuu karịa NMN. A tụrụ NAD na anụ ahụ anakọtara site na usoro okirikiri enzyme. Nsonaazụ gosiri na NMNH mụbara ọkwa NAD na anụ ahụ dị iche iche, na mmetụta dị elu karịa nke NMN. O nwere mmetụta doro anya na imeju na akụrụ, imeju na-abawanye ihe karịrị ugboro ise na akụrụ na-abawanye karịa ugboro ise. ugboro 2.
NMNHna-echebe mkpụrụ ndụ epithelial tubular renal site na mmebi:
N'ime akụrụ, mkpụrụ ndụ epithelial tubular proximal na-enwekarị mmerụ ahụ ischemic n'ihi na ọ na-emetụta metabolism ume ozugbo ma tinye nrụgide dị ukwuu na metabolism NAD na epithelium. Enweghị ahaghị nhata n'okporo ụzọ metabolic yana mbelata ikike ịrụzi usoro epithelial mebiri emebi na-ebute ọrịa akụrụ. Enwere ike ịbawanye ọkwa NAD site na ịgbanye NMNH dịpụrụ adịpụ nke ọma weghachi mkpụrụ ndụ epithelial mebiri emebi? Nlekọta nke NMNH n'okpuru ọnọdụ normoxic mụbara ọdịnaya NAD 5-fold, ebe n'otu ntinye uche, mmetụta NMN dị ntakịrị karịa nke NMNH. Ma ihe mmalite NAD na-abawanye ụba ọdịnaya NAD na sel tubular epithelial renal n'okpuru ọnọdụ hypoxic, ọbụlagodi n'elu ọnọdụ normoxic. A hụrụ ọnọdụ yiri nke ahụ na hepatocytes omenala, ebe nchịkwa nke NMNH mekwara ka mmụba nke metabolites metụtara NAD ruo n'ókè dị ukwuu karịa NMN.
E gbakwunyere NMNH n'oge usoro reoxygenation, na ngosipụta nke renal tubular mercurr marker KIM-1 achọpụtara. Reoxygenation na TEC kpalitere mmụba dị ukwuu na okwu KIM-1, nke na-ebelata nke ọma mgbe ọgwụgwọ NMNH gasịrị, na-egosi na nchịkwa nkeNMNHnwere ike belata n'ụzọ dị irè na nke ọma nbibi nke sel tubular epithelial gbasara akụrụ n'oge hypoxia na reoxygenation.
Ụzọ ahụikeNMNHezigbo ogbugba
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Irene@xahealthway.com
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Ekwentị mkpanaaka: 86 18691558819
Irene@xahealthway.com
www.xahealthway.com
Wechat: 18691558819
WhatsApp: 86 18691558819
