NAD Pre-Cursor mmalite

NAD + bụ coenzyme dị mkpa, onye aha ya bụ nicotinamide adenine dinucleotide. Ọ dị n'ime sel ma na-esonye na ọtụtụ mmeghachi omume biochemical dị mkpa. NAD + na-arụ ọrụ dị mkpa n'ọtụtụ usoro ndu, gụnyere metabolism ume, iku ume cellular, mmezi DNA, ndenye mkpụrụ ndụ ihe nketa, na ịka nká. Ọ nwere ike nweta ma ọ bụ hapụ electrons na ya site na mmeghachi omume biocatalytic dị iche iche. N'ime usoro a, mmeghachi omume nke NAD + nwere ike ịmegharị gụnyere redox, mbelata carbonyl, nnyefe acyl, wdg. Dị ka coenzyme, ọrụ NAD + bụ isi bụ ịnyefe electrons na ions hydrogen na mmeghachi omume enzyme-catalyzed. N'oge usoro a, a na-ebelata NAD + ka ọ bụrụ NADH, si otú ahụ na-enye electrons na hydrogen ion maka mmeghachi omume enzyme ndị ọzọ achọrọ. NAD + adọtala mmasị sayensị dị ukwuu n'afọ ndị na-adịbeghị anya n'ihi na a na-eche na ọ na-etinye aka na usoro ịka nká. Nnyocha achọpụtala na n'oge usoro ịka nká, ọkwa NAD + na sel na-ebelata, na ịgbakwunye NAD + nwere ike ịkwalite metabolism ike cell, mmezi DNA na igbu oge ịka nká. Na mgbakwunye, a chọpụtakwara NAD + ka ọ na-arụ ọrụ dị mkpa n'imezi mmebi DNA, apoptosis, ime enzymes na ịhazi okwu mkpụrụ ndụ ihe nketa. Ugbu a, ndị mmadụ na-eme nchọpụta miri emi na NAD + na ọrụ ya na physiology na pathology, iji chọpụtakwuo banyere ọrụ na ngwa NAD +.