Ịka nká mmadụ bụ iwu okike zuru ụwa ọnụ. "Biochemistry na Cell Biology of Aging" na-achịkọta ọtụtụ iri afọ nke nyocha ịka nká na àgwà ịka nká na mmebi oxidative na ibelata na ọkwa NAD +.
Enwere ike ịhụ na NAD + na-arụ ọrụ dị mkpa n'ime ihe ndị dị ndụ, yana njikọ chiri anya na ọrịa na ọrịa na-efe efe.
A na-akpọ NAD + nicotinamide adenine dinucleotide, ma ọ bụ coenzyme I maka nkenke. Ọ na-etinye aka n'ọtụtụ ọrụ dị iche iche nke physiological n'ime akụkụ ahụ, si otú ahụ na-emetụta mgbake ume, iguzogide mmebi oxidative, nrụzi DNA, na-achịkwa mkpụrụ ndụ ihe nketa na mkpụrụ ndụ ihe nketa na-achịkwa ịka nká na sel, na-ebelata ma ọ bụ ọbụna mechie ụfọdụ mkpụrụ ndụ ihe nketa ịka nká, si otú ahụ na-egbu oge nke ọma. ọganihu nke kwụ n'ahịrị. N'okpuru, ka anyị leba anya n'uju:
1.Ihe dị mkpa nke NAD +
Dị ka otu n'ime metabolites kachasị mkpa na ahụ mmadụ, NAD + anọwo na ọnọdụ kwụ ọtọ nke gụnyere mmepụta ihe ndụ, oriri, mgbasa na mmebi ruo ogologo oge.
Malite na 30s, ọkwa NAD + n'ime ahụ mmadụ ga-egosi ọganihu dị ala ka ndị mmadụ na-eme agadi. Mbelata ọdịnaya NAD + n'ime sel ga-eduga n'ịbelata ikike nrụzi DNA, mee ka mkpokọta DNA mebie ngwa ngwa, wee bute mbibi nke NAD + Ọdịnaya ahụ na-ebelata, na-etolite usoro ọjọọ nke ịka nká ngwa ngwa.
Anyị na-ekwu na NAD + na-etinye aka na nrụzi DNA n'ihi na ọ bụ mkpụrụ nke ezinụlọ PARP. Site na NAD +, PARP nwere ike rụọ ọrụ ya kwekọrọ. N'aka nke ọzọ, PARP bụkwa otu n'ime "ndị na-eri" NAD + na sel. NAD + nke PARP ji mee ihe na-atụgharị ghọọ nicotinamide NAM, wee banye n'ụzọ nnapụta, na NAD + na-arụ ọrụ ọzọ site n'enyemaka nke NAMPT, NMNAT na enzymes ndị ọzọ. Mgbe mkpụrụ ndụ nọ n'okpuru nrụgide (gụnyere usoro nrụzi DNA), a na-emepụta nnukwu NAD + site na ụzọ mgbapụta iji nọgide na-enwe nguzozi n'etiti ọkọnọ na ọchịchọ.
NAD + na-ekere òkè na nrụzi DNA dị ka mkpụrụ nke Sirtuins
Sirtuins bụ ezinụlọ nke protein deacetylase nke nwere ndị otu 7 (SIRT1-SIRT7). SIRT1, SIRT6, na SIRT7 dị na nucleus, SIRT2 na-ekere òkè na cytoplasm, na SIRT3, SIRT4, na SIRT5 bụ protein mitochondrial. Ụfọdụ Sirtuins (karịsịa SIRT1 na SIRT6) na-arụ ọrụ dị mkpa na nrụzi DNA na cellular metabolism mgbe DNA mebiri.
3.NAD + metabolism na ọrụ physiological
01. Nọgide na-enwe redox homeostasis
Idokwa nguzozi nke oxidants intracellular na antioxidants bụ isi ihe maka mkpụrụ ndụ iji nọgide na-arụ ọrụ physiological nkịtị. Agbanyeghị, ihe mkpali ọjọọ dị ka mmetọ, mgbanwe nri na ọrịa nwere ike imebi nguzozi a wee mebie macromolecules dị ndụ dịka DNA na protein. Ịgbakwunye NAD + nwere ike ịrụ ọrụ nchebe oxidative site n'ịbawanye ọkwa na ọrụ nke glutathione na usoro enzymes antioxidant.
02. Jikwaa nkwụsi ike genome
Enweghị NAD + ga-eme ka ihe mgbochi mebie DNA mebiri emebi, na-eme ka ọnụ ọgụgụ buru ibu nke DNA na-agbakọta, na ịgbakwunye NAD + nwere ike inye aka nrụzi DNA.
03. Hazie mgbochi na mbufụt etoju
Na mgbakwunye na NAD + n'onwe ya na-enwe ike belata oke mbufụt site na imeziwanye ọrụ lysosomal, NAMPT enzyme dị mkpa na metabolism ya bụkwa akụkụ dị mkpa nke ịchịkwa mgbochi. Ịgbakwunye NAD + na-enyere aka ịhazi ihe mgbochi na mbufụt.
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Oge nzipu: Dec-26-2023
