Berberine hydrochloride

Ọ nwere mmetụta inhibitory na Escherichia coli, Escherichia coli, Diplococcus pneumoniae, Staphylococcus aureus, Streptococcus, Typhi na amoeba. N'ụlọ ọgwụ, a na-ejikarị ya ebibi ọrịa na nje bacteria. Achọpụtakwara na ngwaahịa a nwere mmetụta mgbochi arrhythmic. Berberine nwere ọrụ mgbochi tumor in vitro ma nwee ike ime ka nzuzo nke mkpụrụ ndụ B16 pụta; dị ka cytarabinehydrochloridenwere mmetụta dị mma na vitro.

Ebumnuche
Isoquinoline alkaloid. Usoro ihe omimi [C20H18NO4]+. A makwaara dị ka berberine. Ọ dị n'ọtụtụ osisi na 10 genera na ezinụlọ 4 gụnyere Berberidaceae. Berberine nwere ike ime ka kristal na-acha odo odo dị ka diethyl ether. Ebe mgbaze 145 ℃. Na-agbaze n'ime mmiri, nke na-adịghị edozi na benzene, ether na chloroform. Berberine bụ quaternary ammonium alkaloid, na solubility nke nnu ya na mmiri dị ntakịrị, dịka ọmụmaatụ, hydrochloride bụ 1:500 na sulfate bụ 1:30. Kristal nke berberine sitere na mmiri ma ọ bụ ethanol dilute nwere 5.5 molecules nke mmiri kristal; Ọ bụrụ na kristal sitere na chloroform, acetone ma ọ bụ benzene, ha nwekwara mkpụrụ ndụ ihe mgbaze kristal kwekọrọ. Enwere ike ịgwọ Berberine na alkali dị iche iche iji nweta ụdị atọ dị iche iche nke berberine: quaternary ammonium form, aldehyde form and alcohol form, n'ime nke quaternary ammonium ụdị bụ ihe kasị kwụsie ike. Berberine nwere mmetụta antibacterial na hemolytic Streptococcus, Staphylococcus aureus, Neisseria gonorrheae, Freundii na Shigella dysenteriae, na-akwalite phagocytosis nke ọbara ọcha. A na-eji Berberine hydrochloride (nke a na-akpọ berberine hydrochloride) n'ọtụtụ ebe na-agwọ ọrịa gastroenteritis, ọrịa ọnyụnyụ bacillary, wdg, ma nweekwa mmetụta ụfọdụ na ụkwara nta, ahụ ọkụ na-acha uhie uhie, nnukwu tonsillitis na ọrịa iku ume.

nkà mmụta ọgwụ
pharmacodynamics
Ọ nwere ụdị dị iche iche nke nje bacteria ma nwee mmetụta antibacterial n'ụdị nje bacteria gram-positive na -adịghị mma na vitro, gụnyere hemolytic Streptococcus, Staphylococcus aureus, na Vibrio cholerae. Meningococci, Shigella dysenteriae, Typhoid bacilli, Diphtheria bacilli, wdg nwere mmetụta mgbochi siri ike. Ha bụ bacteriostatic na obere mkpokọta na sterilizing na nnukwu mkpokọta. Ọ nwekwara mmetụta mgbochi ụfọdụ na nje influenza, amoeba, leptospira, na ụfọdụ fungi anụ ahụ. Nnwale in vitro ekwenyela na berberine nwere ike ịkwalite ikike phagocytic nke leukocytes na sistem reticuloendothelial imeju. Shigella dysenteriae, hemolytic Streptococcus, Staphylococcus aureus, wdg na-adị mfe eguzogide ngwaahịa a. Enweghị nguzogide n'etiti ngwaahịa a na penicillin na streptomycin.

Pharmacokinetics
Ntinye ọnụ na-adịghị mma. Mgbe ịgba ọgwụ mgbochi ahụ gasịrị, ọ na-abanye ngwa ngwa n'ime akụkụ ahụ na anụ ahụ dị iche iche, a na-echekwa itinye uche n'ọbara ruo obere oge. Ịta n'ọbara mgbe ịgba ọgwụ mgbochi intramuscular dị ala karịa nke kacha nta inhibitory itinye uche. A na-ekesa ọgwụ ahụ n'ọtụtụ ebe, ọkachasị n'ime obi, ọkpụkpụ, ngụgụ na imeju. Oge ndowe n'ime anụ ahụ dị mkpụmkpụ, ma ọ bụ naanị ọnụọgụ ọnụọgụ ga-adị mgbe awa 24 gachara. Ọtụtụ n'ime ọgwụ ndị ahụ bụ metabolized ma kpochapụ n'ime ahụ, ma ọ bụ ihe na-erughị 5% nke ọgwụ a na-enye ka a na-ewepụ n'ụdị mbụ n'ime awa 48.
Dị ka akụkọ ndị na-adịbeghị anya si kwuo, a kwenyere na ngwaahịa a nwere ike belata ọnụ ọgụgụ nke pili n'elu nje bacteria, na-egbochi nje bacteria na-ejikọta ya na sel mmadụ, ma nwee mmetụta ọgwụgwọ. Ngwaahịa a nwekwara mmetụta na Helicobacter ma nwee ike ibelata gastritis, ọnya afọ na duodenal ọnya.

Ọ nwere nkwarụ ma jiri nlezianya mee ya
Ọ bụ ezie na enwere ike iji ya na ụmụaka, a machibidoro ya na ụmụaka nwere ụkọ glucose-6-phosphate dehydrogenase eketa n'ihi na ngwaahịa a nwere ike ime ka anaemia hemolytic na-eduga na jaundice.

Mmeghachi omume ọjọọ
(1) Mmeghachi omume ọjọọ nke ọnụ na-adịkarị ụkọ, na-enwe ọgbụgbọ, ọgbụgbọ, ọkụ ọkụ na ahụ ọkụ ọgwụ, nke na-apụ n'anya ma kwụsịchaa ọgwụ ahụ.
(2) Intravenous injection ma ọ bụ infusion nwere ike ime ka mmeghachi omume dị ka vasodilation, ọbara mgbali elu, na ịda mbà n'obi obi. N'ọnọdụ ndị siri ike, Aspen syndrome nwere ike ime, na ọbụna ọnwụ. China ekwuputala mkpochapụ ịgba ọgwụ dị iche iche nke berberine hydrochloride.
Mmadụ ole na ole na-enwe ahụ erughị ala afọ ma ọ bụ afọ, afọ ntachi ma ọ bụ afọ ọsịsa.

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