A na-ewere NMN ka ọ kacha mmaNAD+ precursor n'ime ahụ mmadụ. Agbanyeghị, ndị ọkà mmụta sayensị na-agbanwe agbanwe kwenyere na nnabata nke NMN nwekwara ike ịnwe oke ruo n'ókè ụfọdụ. Naanị site na ịgbakwunye nnukwu doses nke NMN nwere ike nweta mmetụta mgbanwe dị irè.
Iji mezuo nke a, Bangtai mepụtara liposome nke ọmaNMN, ndị escort express nke NMN, ma malite nnukwu mmepụta ihe.
Gịnị bụliposomes NMN ? Ka anyị buru ụzọ lelee ihe liposomes bụ?
Liposomes bụ vesicles mere nke phospholipid molecules - otu ụmụ irighiri ihe na-emejupụta cell membranes.
Mkpụrụ ndụ phospholipid nwere isi hydrophilic phosphate na ọdụ ọdụdụ acid fatty abụọ. Njirimara ndị a na-eme ka liposomes bụrụ ihe na-ebu maka ogige hydrophobic na hydrophilic.
N'ihi nnabata dị ala na bioavailability nke capsules oriri ọdịnala ọdịnala, ntinye nke hydrophilic na hydrophobic nri na liposomes na-enye ohere ka ihe ndị na-arụ ọrụ na-agabiga mbibi nke sistemu afọ.
Iji hapụ ụmụ irighiri ihe echedoro na saịtị a na-eme ihe, bilayer lipid na-ejikọta ya na ihe ndị ọzọ bilayers (dịka ọmụmaatụ, membranes cell), na-ebuga ọdịnaya lipsomal ozugbo ma na-adaba n'ime sel na anụ ahụ.
N'ikwu ya n'ụzọ dị mfe karị, liposomes dị ka ụgbọ ala na-ebuga ego nke molecule, na-echebe "ego (ọgwụ)" dị n'ime ụgbọ ala ahụ pụọ n'ohi n'ụzọ imeju na akụkụ ahụ ndị ọzọ.
N'ezie, ngwaahịa liposome enweelarị akụkọ ịga nke ọma ole na ole. Ụfọdụ ndị mmadụ na-eji liposomes na-ekpuchi Fisetin, na bioavailability na-abawanye ugboro 27; bioavailability nke liposomal vitamin B-12 usoro bụ 3-5 ugboro karịa mbadamba; Liposomal berberine nwere ike ịbawanye oge mgbasa ozi ugboro 23-46.
Ya mere, ọ dị mkpa iji encapsulateNMNna liposomes?
Na-ekpe ikpe site na usoro nkwenye kwadoro, NMN na-adabere na onye na-ebugharị slc12a8 na obere eriri afọ na-ebuga ya n'ime sel, wee mee ka ọkwa NAD + dị na akụkụ dị iche iche na anụ ahụ dị iche iche dị ka ọbara na-ekesa.
Agbanyeghị, NMN na-emebi ngwa ngwa mgbe mmiri na okpomọkụ ruru ogo ụfọdụ. Ugbu a, ọtụtụ NMN n'ahịa dị n'ụdị capsules na mbadamba. Mgbe ị were NMN capsules ma ọ bụ mbadamba, ọtụtụ n'ime ha na-eweda ala na afọ. Naanị obere akụkụ nke NMN na-erute obere eriri afọ, nke bụ ọkara nsonaazụ ya na mgbalị ugboro abụọ.
Mgbe ejiri liposomes kpuchie NMN, enwere ike ichekwa NMN ka ọ ruo ebe a na-achọsi ike.
Nke mbụ, NMN liposomal nwere ike ịgafe mmebi nke usoro nri nri, na-enye ya ohere ịbanye na mgbasa ọbara ozugbo wee rute akụkụ ahụ dị iche iche.
Nke abuo, liposomal NMN na-ewepụta mkpụrụ ndụ NMN site na ngwakọta akpụkpọ ahụ, nke na-egbu oge nkwụsị nke mkpụrụ ndụ NMN ma na-abawanye oge mgbasa ha na arịa ọbara, na-ebelata macrophages na reticuloendothelial system (RES) na liposomal NMN. Mgbari nri, ma na-eme ka ọnụọgụ njide nke molekul NMN dịkwuo mma.
Na mgbakwunye, NMN etinyere na liposomes na-egbochi metabolism, na ụmụ irighiri ọgwụ na-arụ ọrụ naanị mgbe ha rutere ebe a na-achọsi ike ma tọhapụ ya na liposomes.
N'ikpeazụ, Liposomal NMN bụ ụzọ dị irè iji gbochie mmebi nke NMN na usoro gastric.
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Oge nzipu: Eprel 16-2024
